1-Deoxysphingolipids Tempt Autophagy Resulting in Lysosomal Lipid Substrate Accumulation: Tracing the Impact of 1-Deoxysphingolipids on Ultra-Structural Level using a Novel Click-Chemistry Detection
C. Lamberz, M. R. Hesse, G. Kirfel
This study identifies deoxySLs' impact on cellular ultra-structure by linking them to mitochondrial and ER damage, autophagy, and lysosomal lipid accumulation.
bioRxiv · Jan 21, 2021 · PreprintCell Biology