SARS-CoV-2 spike protein induces inflammation via TLR2-dependent activation of the NF-κB pathway
S. Khan, M. S. Shafiei, C. Longoria, J. Schoggins, R. C. Savani, H. Zaki
This study shows that SARS-CoV-2 spike protein induces inflammation in macrophages and epithelial cells via TLR2-dependent NF-κB activation, suggesting TLR2 as a therapeutic target for COVID-19.
bioRxiv · Mar 16, 2021Immunology