S. Khan

Aspergillus-mediated allergic airway inflammation is triggered by dendritic cell recognition of a defined spore morphotype, a process that can be targeted via antifungal therapeutics.

This study identifies a specific stage of Aspergillus fumigatus spore development that activates dendritic cells to trigger allergic airway inflammation and shows antifungal drugs can reduce this process.

MICAL2 Is a Super Enhancer Associated Gene that Promotes Pancreatic Cancer Growth and Metastasis

This study identifies MICAL2 as a super enhancer-associated gene that promotes pancreatic cancer growth and metastasis through multiple molecular mechanisms.

Reprogramming SREBP1-dependent lipogenesis and inflammation in high-risk breast with licochalcone A: a novel path to cancer prevention

This study shows licochalcone A suppresses breast cancer growth by targeting SREBP1-dependent lipogenesis and inflammation.

PCIF1 is partly cytoplasmic, dynamically localizes to stress granules and binds mRNA coding regions upon oxidative stress

This study shows PCIF1 is cytoplasmic, localizes to stress granules, and binds mRNA coding regions during oxidative stress, suggesting a role in RNA surveillance independent of its methyltransferase activity.

PROTAC-mediated dual degradation of BCL-xL and BCL-2 is a highly effective therapeutic strategy in small-cell lung cancer

This paper evaluates a dual BCL-xL/BCL-2 degrader, 753b, showing it effectively reduces tumor viability and growth in SCLC models while avoiding platelet toxicity seen with navitoclax.

Single-cell transcriptomics reveals colonic immune perturbations during amyloid-β driven Alzheimer's disease in mice

This study uses single-cell RNA sequencing to identify immune changes in the colon of Alzheimer's disease mice, finding reduced antibody-secreting cells and altered immune trafficking.

Influence of different landscape configurations on insect pollinators of important horticultural crops in a western Himalayan landscape

This study evaluates how different landscape configurations affect insect pollinator diversity, richness, and abundance in horticultural crops in the western Himalayas.

High throughput screening identifies broad-spectrum Coronavirus entry inhibitors

This study uses high-throughput screening to identify small molecule inhibitors that block coronavirus entry, finding a novel broad-spectrum antiviral.

Targeting cancer with small molecule pan-KRAS degraders

A single small molecule degrader targets 13 out of 17 prevalent oncogenic KRAS alleles, inhibiting growth of KRAS-driven cancer cell lines and inducing tumour regression in vivo.

Controlling pericellular oxygen tension in cell culture reveals distinct breast cancer responses to low oxygen tensions

This study shows that controlling incubator gas phase O2 is insufficient to control pericellular O2 in cell culture, revealing non-monotonic breast cancer responses to low O2.

B Cells Promote T Cell Immunosenescence and Mammalian Aging Parameters

The paper identifies B cells as drivers of T cell immunosenescence and aging, showing that targeting B cells with CD20 antibodies can reverse age-related T cell dysfunction.

Droplet based low input proteomic platform for rare cell populations

DROPPS enables high-fidelity proteomic profiling of rare cell populations with low input, revealing CD36 as a marker of progenitor capacity in mammary basal cells.

Diet-induced plasticity of life-history traits and gene expression in outbred Drosophila melanogaster population

This study examines how different macronutrient diets affect life-history traits and gene expression in Drosophila melanogaster, finding that carbohydrate-reduced diets accelerate development and reproduction while high carbohydrate diets reduce lifespan.

The proteomic landscape of genotoxic stress-induced micronuclei

The paper profiles the proteome of micronuclei, cytoplasm, and nuclei in human cells exposed to genotoxins, revealing distinct proteomic features and their implications for DNA damage and chromothripsis.

Broad-Spectrum Heavily Mutated Monoclonal Antibody Isolated from COVID-19 Convalescent Vaccinee with Capacity to Neutralize SARS-CoV2 Variants Ranging from B.1 to BQ.1.1

The paper isolates and characterizes Acovimab, a broadly neutralizing monoclonal antibody against SARS-CoV-2 variants, showing potent neutralization against most variants except XBB.1.5 and synergistic activity with Sotrovimab.

High performance anion exchange chromatography purification of probiotic bacterial extracellular vesicles enhances purity and anti-inflammatory efficacy

This study develops a method combining tangential flow filtration and high performance anion exchange chromatography to purify bacterial extracellular vesicles, improving their purity and anti-inflammatory efficacy.

Anthropogenic Threats and Conservation Practices: Evaluating LULC Changes in Relocated Villages of Panna Tiger Reserve, Madhya Pradesh, India

This study evaluates land use and land cover changes in relocated villages within Panna Tiger Reserve over 15 years, finding increased forest cover and biodiversity in these areas.

Unravelling the anticancer and enzyme inhibition potential of different classes of compounds including a new steroid, isolated from Cassia mimosoïdes

This study isolates and evaluates compounds from Cassia mimosoïdes, finding some exhibit strong urease inhibition and one shows significant β-glucosidase inhibition, suggesting potential for anticancer and enzyme-targeted therapies.

Discovery of decreased ferroptosis in male colorectal cancer patients with KRAS mutations

This study identifies suppressed ferroptosis in male colorectal cancer patients with KRAS mutations, linking it to poorer survival outcomes.

Rad51 inhibition sensitizes non-replicating quiescent cells to UVB radiation and transcription stress

The paper shows Rad51 promotes survival of quiescent cells under UVB and transcription stress, independent of NER.

Co-targeting BCL-XL and MCL-1 with DT2216 and AZD8055 synergistically inhibits small-cell lung cancer growth without causing on-target toxicities in mice

The Solvation of the E. coli CheY Phosphorylation SiteMapped by XFMS

The paper reanalyzes XFMS data to show polar residues around the phosphorylated CheY site form a solvation network stabilizing the apo-CheY fold, with 18R as a central node.

Inhibition of Aromatase by Hops, Licorice Species, and their bioactive compounds in Postmenopausal Breast Tissue

The paper investigates the aromatase inhibitory effects of hops, licorice species, and their bioactive compounds in postmenopausal breast tissue, identifying potent inhibitors with potential for breast cancer prevention.

A cobB like protein in Oryza sativa indica regulates the mitochondrial machinery under stress conditions

This paper identifies a new class III sirtuin in Oryza sativa indica that regulates mitochondrial and nuclear processes under stress conditions.

In vitro and in vivo antioxidant therapeutic evaluation of Dodonaea viscosa Jacq.

This paper evaluates the antioxidant potential of Dodonaea viscosa Jacq. extracts in vitro and in vivo, finding higher antioxidant activity in leaves and non-toxic effects in rats.

Extracellular vesicle fusion visualized by cryo-EM

This study visualizes EV membrane fusion using cryo-EM and shows EVs remain fusogenic after acidification and re-neutralization, unlike retroviruses.

Prioritized single-cell proteomics reveals molecular and functional polarization across primary macrophages

The paper introduces pSCoPE, a single-cell proteomics method that improves sensitivity, completeness, and depth, enabling analysis of protein variation in macrophages.

In vitro direct regeneration and Agrobacterium tumefaciens mediated in planta transformation of Ocimum sanctum L.

This paper develops an in vitro direct regeneration and Agrobacterium tumefaciens-mediated transformation protocol for Ocimum sanctum to enable genetic modification and trait improvement.

Characterization of the minimal residual disease state reveals distinct evolutionary trajectories of human glioblastoma

This study characterizes the minimal residual disease state in glioblastoma, revealing distinct evolutionary trajectories and immunomodulatory signatures associated with recurrence.

GWAS and functional studies implicate a role for altered DNA repair in the evolution of drug resistance in Mycobacterium tuberculosis

This study identifies DNA repair gene mutations linked to drug resistance in Mycobacterium tuberculosis through GWAS and functional experiments.