Lung tumor-infiltrating Treg have divergent transcriptional profiles and function linked to checkpoint blockade response
A. G. Dykema, J. Zhang, B. Zhang, L. S. Cheung, Z. Zeng, C. M. Cherry, T. Li, J. X. Caushi, M. Nishimoto, S. Connor, Z. Ji, A. J. Munoz, W. Hou, W. Zhan, D. Singh, , K. N. Smith
The paper identifies 10 subsets of lung cancer-infiltrating Tregs, showing one subset is suppressive and linked to anti-PD-1 resistance while another is Th1-like and associated with PD-1 response.
bioRxiv · Dec 13, 2022 · PreprintImmunology