Z. Ji

TurboID-mediated surface protein biotinylation to inhibit the growth of Staphylococcus aureus

This study uses TurboID-mediated biotinylation of surface proteins to inhibit the growth and virulence of multiple S. aureus strains.

AlphaFold2-Guided Functional Screens Reveal a Conserved Antioxidant Protein at ER Membranes

The paper identifies ERGU-1 as a conserved antioxidant protein at ER membranes using AlphaFold2 and functional screens in C. elegans, showing its role in H2O2 detoxification and antioxidant defense.

Single-cell transcriptomics reveals immunosuppressive microenvironment and highlights stumor-promoting macrophage cells in Glioblastoma

This study uses single-cell transcriptomics to analyze GBM tumor microenvironment, identifying immunosuppressive macrophage subtypes and exhausted NK cells, suggesting therapeutic targets.

Bidirectional substrate shuttling between the 26S proteasome and the Cdc48 ATPase promotes protein degradation

The paper demonstrates bidirectional substrate shuttling between the 26S proteasome and Cdc48 ATPase in yeast, showing how this process facilitates protein degradation.

Identification of the glycosylphosphatidylinositol-specific phospholipase A2 (GPI-PLA2) of GPI fatty acid remodelling in Trypanosoma brucei

This paper identifies a gene encoding GPI-PLA2 in Trypanosoma brucei, showing its role in GPI fatty acid remodelling and anchor sidechain size regulation.

Distinct Myeloid Derived Suppressor Cell Populations Promote Tumor Aggression in Glioblastoma

This study identifies two unique myeloid-derived suppressor cell populations in glioblastoma that promote tumor growth and immune evasion.

Lung tumor-infiltrating Treg have divergent transcriptional profiles and function linked to checkpoint blockade response

The paper identifies 10 subsets of lung cancer-infiltrating Tregs, showing one subset is suppressive and linked to anti-PD-1 resistance while another is Th1-like and associated with PD-1 response.

CRISPR/FnCas12a-mediated efficient multiplex and iterative genome editing in bacterial plant pathogens without donor DNA templates

This paper develops a CRISPR/Cas12a-based genome editing method for bacterial plant pathogens without donor DNA, enabling efficient gene knockout and multiplex editing in Xanthomonas oryzae pv. oryzae.

Controlling taxa abundance improves metatranscriptomics differential analysis

The paper shows that controlling for both DNA and taxa abundances improves differential analysis in metatranscriptomics data.

Translocation of polyubiquitinated protein substrates by the hexameric Cdc48 ATPase

This study elucidates how the Cdc48 ATPase complex unfolds and translocates polyubiquitinated protein substrates through cooperative binding with Ufd1/Npl4.

Regulation of drought tolerance in Arabidopsis involves PLATZ4-mediated transcriptional suppression of PIP2;8

This study identifies PLATZ4's role in enhancing drought tolerance and ABA sensitivity in Arabidopsis by suppressing PIP2;8 and upregulating stress-related genes through interaction with AITR6.

Resurrection of human endogenous retroviruses during aging reinforces senescence

This study shows that reactivation of human endogenous retroviruses during aging promotes cellular senescence and tissue degeneration, and that blocking this reactivation can alleviate aging.

Tumor expressed CD95 causes suppression of anti-tumor activity of NK cells in a model of triple negative breast cancer

This study shows that CD95 expression by tumor cells suppresses NK cell anti-tumor activity in triple negative breast cancer, leading to reduced tumor growth in immune-competent mice.

Proteomic identification of the UDP-GlcNAc : PI α1-6 GlcNAc-transferase subunits of the glycosylphosphatidylinositol biosynthetic pathway of .

The paper identifies subunits of the UDP-GlcNAc : PI α1-6 GlcNAc-transferase complex in Trypanosoma brucei using proteomics and immunoprecipitation.

Large-scale prediction of key dynamic interacting proteins in multiple cancers

The paper predicts key dynamic interacting proteins in multiple cancers and identifies their functional characteristics and network roles.

Composite modeling of leaf shape across shoots discriminates Vitis species better than individual leaves

The paper models leaf shape changes across shoots in Vitis species and finds composite leaves better predict species identity than individual leaves.

Single-cell analysis supports a luminal-neuroendocrine transdifferentiation in human prostate cancer

The paper uses single-cell RNA sequencing to show neuroendocrine prostate cancer cells originate from luminal-like cells, not basal cells, and identifies associated gene signatures.

Non-canonical open reading frames encode functional proteins essential for cancer cell survival

The paper identifies non-canonical open reading frames (ORFs) that encode functional proteins essential for cancer cell survival, with one example, GREP1, showing preferential essentiality in breast cancer.

Thousands of novel unannotated proteins expand the MHC I immunopeptidome in cancer

The paper identifies thousands of novel unannotated proteins in cancer that contribute to the MHC I immunopeptidome, expanding potential targets for immunotherapy.

Decoding WW Domain Tandem-mediated Target Recognitions in Tissue Growth and Cell Polarity

The paper identifies specific target proteins bound by WW domain tandems of KIBRA and MAGI with high affinity and specificity, revealing new binding partners and mechanisms.

Regulatory network controlling tumor-promoting inflammation in human cancers

The paper identifies a transcriptional regulatory network involving STAT3, NF-κB, and AP-1 that drives tumor-promoting inflammation in cancers, linking inflammation to immune infiltration and genome instability.

Multi-hierarchical Profiling the Structure-Activity Relationships of Engineered Nanomaterials at Nano-Bio Interfaces

This study develops a multi-hierarchical nano-SAR assessment for Fe2O3 nanomaterials, revealing how their properties influence bio-effects like cell migration and inflammation.