Author

L. S. Cheung

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2 Immunology· 2 Biochemistry· 1 Cell Biology· 1 Plant Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell type annotation· 4 Organism:Arabidopsis· 3 Organism:mouse· 3 Research Focus:clustering· 2 Research Focus:differential expression· 2 Organism:plant (other)· 2 Assay:proteomics· 2

Frequent Co-Authors

A. G. Dykema· 2 shared D. C. Bergmann· 2 shared D. M. Pardoll· 2 shared D. VanDyke· 2 shared J. B. Spangler· 2 shared J. Park· 2 shared L. M. Tomasovic· 2 shared R. Varnau· 2 shared

Activity by Year

2020-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersImmunology

A. G. Dykema

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Author profile →

7 papers

Recent·Most cited

The Arabidopsis SWEET1 and SWEET2 uniporters recognize similar substrates despite differences in subcellular localization

S. Gwon, J. Park, A. K. M. M. Huque, L. S. Cheung

The paper uses SweetTrac2 to show SWEET1 and SWEET2 recognize similar substrates but with different affinities, supported by sequence and mutagenesis analysis.

bioRxiv · May 30, 2023Biochemistry

Lung tumor-infiltrating Treg have divergent transcriptional profiles and function linked to checkpoint blockade response

A. G. Dykema, J. Zhang, B. Zhang, L. S. Cheung, Z. Zeng, C. M. Cherry, T. Li, J. X. Caushi, M. Nishimoto, S. Connor, Z. Ji, A. J. Munoz, W. Hou, W. Zhan, D. Singh, , K. N. Smith

The paper identifies 10 subsets of lung cancer-infiltrating Tregs, showing one subset is suppressive and linked to anti-PD-1 resistance while another is Th1-like and associated with PD-1 response.

bioRxiv · Dec 13, 2022 · PreprintImmunology

Engineered human cytokine/antibody fusion proteins expand regulatory T cells and confer autoimmune disease protection

D. VanDyke, M. Iglesias, J. Tomala, A. Young, J. Smith, J. A. Perry, E. Gebara, A. R. Cross, L. S. Cheung, A. G. Dykema, B. T. Orcutt-Jahns, T. Henclova, J. Golias, J. Balolong, L. M. Tomasovic, , J. B. Spangler

The paper engineers a cytokine/antibody fusion protein that selectively expands regulatory T cells and protects against autoimmune diseases in mouse models.

bioRxiv · May 29, 2022Bioengineering

Tuning of self-renewing capacity in theArabidopsis stomatal lineage by hormonaland nutrition regulation of asymmetric celldivisions

Y. Gong, J. Alassimone, R. Varnau, N. Sharma, L. S. Cheung, D. C. Bergmann

The paper identifies how ethylene and glucose signaling regulate asymmetric cell divisions in Arabidopsis stomatal lineage stem cells, showing their impact on cell polarity and developmental outcomes.

bioRxiv · Sep 16, 2020Plant Biology

Quantitative and dynamic cell polarity tracking in plant cells

Y. Gong, R. Varnau, E.-S. Wallner, D. C. Bergmann, L. S. Cheung

The paper introduces POME, a semi-automated pipeline for quantifying cell polarity, and applies it to study polarity dynamics in plant cells during asymmetric divisions.

bioRxiv · Sep 12, 2020Cell Biology

Quantitative analysis of transporter activity biosensors

J. Park, T. M. Chavez, W. Frommer, L. S. Cheung

The paper designs genetically-encoded biosensors to measure SWEET transporter activity in plants and develops a mathematical model to explain their response.

bioRxiv · Sep 3, 2020Bioengineering

IL-4 receptor targeting as an effective immunotherapy against triple-negative breast cancer

S. Parveen, S. Siddharth, L. S. Cheung, A. Kumar, J. R. Murphy, D. Sharma, W. R. Bishai

This paper demonstrates that DABIL-4, a fusion toxin targeting IL-4R, effectively reduces TNBC tumor growth and metastasis by depleting both tumor cells and immunosuppressive cells in the tumor microenvironment.

bioRxiv · Aug 5, 2020 · PreprintImmunology