W. Zhan

Numerical Simulation of Transdermal Delivery of Drug Nanocarriers Using Solid Microneedles

This study uses numerical simulation to analyze drug nanocarrier transport through skin layers and blood, finding diffusion dominance and key parameters for improving delivery effectiveness.

Fortuitous Somatic Mutations during Antibody Evolution Endow Broad Neutralization against SARS-CoV-2 Omicron Variants

The paper identifies an antibody with broad neutralization against SARS-CoV-2 Omicron variants and shows how somatic mutations enhance its neutralization breadth and potency.

Linking fluid-axons interactions to the macroscopic fluid transport properties of the brain

This paper establishes the link between microscale fluid-axon interactions and macroscopic brain transport properties using simulations, introducing an anisotropic pressure-dependent permeability tensor.

Lung tumor-infiltrating Treg have divergent transcriptional profiles and function linked to checkpoint blockade response

The paper identifies 10 subsets of lung cancer-infiltrating Tregs, showing one subset is suppressive and linked to anti-PD-1 resistance while another is Th1-like and associated with PD-1 response.

Structure of the human UBR5 E3 ubiquitin ligase

This paper determines the dimer and tetramer structures of human UBR5, revealing its oligomerization mechanism and functional implications for cancer.

An environmentally ultrasensitive fluorine probe to resolve protein conformational ensembles by 19F NMR and cryo-EM

This paper introduces a fluorine probe that enhances 19F NMR sensitivity for studying protein conformational changes, validated by cryo-EM structural analysis.

A potent SARS-CoV-2 antibody neutralizes Omicron variant by disassembling the spike trimer

This paper identifies a potent SARS-CoV-2 antibody, 553-49, that neutralizes the Omicron variant by targeting a conserved epitope and disassembling spike trimers.

Combating the SARS-CoV-2 Omicron variant with non-Omicron neutralizing antibodies

This study designs bispecific antibodies from non-Omicron neutralizing antibodies that effectively neutralize the Omicron variant and related sarbecoviruses.

Asymmetric Pendrin Homodimer Reveals its Molecular Mechanism as Anion Exchanger

The paper determines the asymmetric homodimer structure of mouse pendrin using cryo-EM, revealing its electroneutral anion exchange mechanism and pathogenetic mutation properties.

Broad neutralization of SARS-CoV-2 variants by an inhalable bispecific single-domain antibody

This paper identifies two conserved regions on the Omicron RBD recognized by broadly neutralizing antibodies and develops an inhalable bispecific antibody with broad neutralization and therapeutic efficacy in mice.

Artemisinin-based hybrids produce intracellular proteasome inhibitors that overcome resistance in Plasmodium falciparum

This study designs artezomibs, artemisinin-proteasome inhibitor hybrids, which overcome resistance in Plasmodium falciparum by targeting proteasomes, including those with mutations.

Transcriptome analysis of the Larimichthys polyactis under heat and cold stress

This study identifies differentially expressed genes and pathways in small yellow croaker liver under heat and cold stress, providing insights into temperature stress responses for aquaculture improvement.