Macrophages utilize a bet-hedging strategy for antimicrobial activity in phagolysosomal acidification
Q. Dragotakes, K. Stouffer, M. S. Fu, Y. Sella, C. Youn, I. Yoon, C. M. Leon-Rodriguez, J. B. Freij, A. Bergman, A. Casadevall
The paper shows macrophages use a bet-hedging strategy by stochastically acidifying phagolysosomes to reduce variation in antimicrobial effectiveness.
bioRxiv · Mar 11, 2020Microbiology