Epigenetic Small-Molecule Screen for Inhibition and Reversal of Acinar Ductal Metaplasia in Mouse Pancreatic Organoids
K. R. Atanasova, C. M. Perkins, R. Ratnayake, J. Jiang, Q.-Y. Chen, T. D. Schmittgen, H. Luesch
The paper screens epigenetic small molecules to inhibit and reverse acinar ductal metaplasia in mouse pancreatic organoids, identifying several effective compounds with improved activity over TSA.
bioRxiv · Nov 27, 2023 · PreprintCancer Biology