Author

L. M. Brown

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Physiology· 2 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 4 Assay:proteomics· 3 Research Focus:cell type annotation· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

J. K. Chakrabarty· 2 shared A. A. Lakhani· 1 shared A. Aslan· 1 shared A. Avila· 1 shared A. J. Gifford· 1 shared A. J. Shih· 1 shared A. M. Fordham· 1 shared A. M. Taylor· 1 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 6 mutual co-author links

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2 shared papersPhysiology

J. K. Chakrabarty

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Comprehensive multi-platform tyrosine kinase profiling reveals novel actionable FGFR aberrations across pediatric and AYA sarcomas

A. M. Fordham, L. M. Brown, C. Mayoh, A. Salib, Z. A. Barger, M. Wong, T. C. C. L. K. Sian, J. Xie, K. Gunther, P. Trebilcock, R. L. Terry, P. Barahona, P. Ajuyah, A. Sherstyuk, A. Avila, , E. D. Fleuren

The paper identifies FGFR aberrations as actionable targets in pediatric and AYA sarcomas using multi-platform profiling and shows FGFR inhibitors can inhibit tumor growth in PDX models.

bioRxiv · Jul 19, 2023 · PreprintCancer Biology

Septin 7 Interacts With Numb To Preserve Sarcomere Structural Organization And Muscle Contractile Function.

R. De Gasperi, L. Csernoch, B. Dienes, M. Gonczi, J. K. Chakrabarty, S. Goeta, A. Aslan, C. A. Toro, D. Karasik, L. M. Brown, M. Brotto, C. P. Cardozo

The paper identifies Septin 7 as a Numb binding partner that helps maintain sarcomere structure and muscle function in aging skeletal muscle.

bioRxiv · May 11, 2023Physiology

Oncogene-like addiction to aneuploidy in human cancers

V. Girish, A. A. Lakhani, C. M. Scaduto, S. L. Thompson, L. M. Brown, R. A. Hagenson, E. L. Sausville, B. E. Mendelson, D. A. Lukow, M. L. Yuan, P. K. Kandikuppa, E. C. Stevens, S. N. Lee, B. Salovska, W. Li, , J. M. Sheltzer

This study demonstrates that trisomy of chromosome 1q is essential for malignant growth in cancers and shows that TP53 mutations are mutually exclusive with 1q aneuploidy.

bioRxiv · Jan 9, 2023Cancer Biology

Proteomic and single-cell transcriptomic dissection of human plasmacytoid dendritic cell response to influenza virus

M. H. Ghanem, A. J. Shih, H. Khalili, E. Werth, J. K. Chakrabarty, L. M. Brown, K. R. Simpfendorfer, P. K. Gregersen

The paper profiles the proteomic and single-cell transcriptomic responses of human plasmacytoid dendritic cells to influenza virus, revealing diverse secreted proteins and transcriptional fates.

bioRxiv · Nov 1, 2021Immunology

The Impact of Body Mass Index on Physical Activity and Cardiac Workload

M. J. Bloom, L. M. Brown, S. R. Jost, A. S. I. D. Lang, N. V. Mankin, Z. W. Mast, E. R. McMahan, J. A. Merheb, P. P. Nelson, J. C. Nnaji, E. F. Valderrama

This study examines the relationship between BMI, physical activity, and cardiac workload in university students, finding that abnormal BMI values correlate with higher cardiac workload despite lower physical activity.

bioRxiv · Sep 26, 2021 · PreprintPhysiology

Pseudomonas aeruginosa PA14 produces R-bodies, extendable protein polymers with roles in host colonization and virulence

B. Wang, Y.-C. Lin, A. Vasquez-Rifo, J. Jo, A. Price-Whelan, S. Tao McDonald, L. M. Brown, C. Sieben, L. E. Dietrich

This study shows Pseudomonas aeruginosa PA14 produces R-bodies, which are involved in virulence against nematodes through ribosome cleavage and translational inhibition.

bioRxiv · Oct 26, 2020Microbiology