Deficiency of macrophage-derived Dnase1L3 causes lupus-like phenotypes in mice
M. Engavale, C. J. Hernandez, A. Infante, T. LeRoith, E. Radovan, L. Evans, J. Villarreal, C. M. Reilly, R. B. Sutton, P. A. Keyel
This study shows that reducing macrophage-derived Dnase1L3 in mice causes mild lupus-like symptoms, suggesting its role in preventing lupus.
bioRxiv · Apr 17, 2023Immunology