Author

J. Villarreal

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Organism:human· 2 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1

Frequent Co-Authors

R. B. Sutton· 3 shared M. Engavale· 2 shared P. A. Keyel· 2 shared A. Infante· 1 shared B. Mapp· 1 shared C. J. Hernandez· 1 shared C. M. Reilly· 1 shared C. Myers· 1 shared

Activity by Year

2022-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersCell Biology

R. B. Sutton

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

The Mouse Epididymal Amyloid Matrix: A Mammalian Counterpart of a Bacterial Biofilm

C. Myers, G. R. Atkins, J. Villarreal, R. B. Sutton, G. A. Cornwall

The paper identifies the mouse epididymal amyloid matrix as a structural and functional analog of bacterial biofilms, protecting spermatozoa through components like eDNA, eRNA, and mucin-like polysaccharides.

iScience · Jun 1, 2024Peer-reviewedCell Biology

Deficiency of macrophage-derived Dnase1L3 causes lupus-like phenotypes in mice

M. Engavale, C. J. Hernandez, A. Infante, T. LeRoith, E. Radovan, L. Evans, J. Villarreal, C. M. Reilly, R. B. Sutton, P. A. Keyel

This study shows that reducing macrophage-derived Dnase1L3 in mice causes mild lupus-like symptoms, suggesting its role in preventing lupus.

bioRxiv · Apr 17, 2023Immunology

Structural features of Dnase1L3 responsible for serum antigen clearance

J. J. McCord, M. Engavale, E. Masoumzadeh, J. Villarreal, B. Mapp, M. P. Latham, P. A. Keyel, R. B. Sutton

This study identifies structural features of Dnase1L3 that enable its unique ability to degrade antigenic DNA complexes, preventing autoimmunity.

bioRxiv · Jan 19, 2022Biochemistry

RNA binding to human METTL3-METTL14 restricts N6-deoxyadenosine methylation of DNA in vitro

S. Qi, J. Mota, S.-H. Chan, J. Villarreal, N. Dai, S. Arya, R. A. Hromas, M. K. Rao, I. R. Correa, Y. K. Gupta

This study investigates how the METTL3-METTL14 complex binds and methylates DNA and RNA, revealing distinct preferences for single-stranded DNA and structured RNA.

bioRxiv · Jan 8, 2022Biochemistry