Author

P. A. Keyel

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1 Cell Biology· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 5 Assay:proteomics· 3 Research Focus:cell type annotation· 2 Organism:human· 2 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

R. B. Sutton· 3 shared J. Villarreal· 2 shared M. Engavale· 2 shared R. Thapa· 2 shared A. Infante· 1 shared A. Snow· 1 shared B. Mapp· 1 shared C. Frankfater· 1 shared

Activity by Year

2022-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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3 shared papersBiophysics

R. B. Sutton

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Pathogenic Mutations in the C2A Domain of Dysferlin form Amyloid that Activates the Inflammasome.

I. L. Scott, M. J. Dominguez, A. Snow, F. M. Harsini, J. Williams, K. L. Fuson, R. Thapa, P. Bhattacharjee, G. A. Cornwall, P. A. Keyel, R. B. Sutton

This study shows that C2A domain mutations in dysferlin cause amyloid formation, which activates the NLRP3 inflammasome and leads to inflammation and muscle dysfunction in Limb-Girdle Muscular Dystrophy Type-2B/2R.

bioRxiv · Apr 24, 2023 · PreprintBiophysics

Deficiency of macrophage-derived Dnase1L3 causes lupus-like phenotypes in mice

M. Engavale, C. J. Hernandez, A. Infante, T. LeRoith, E. Radovan, L. Evans, J. Villarreal, C. M. Reilly, R. B. Sutton, P. A. Keyel

This study shows that reducing macrophage-derived Dnase1L3 in mice causes mild lupus-like symptoms, suggesting its role in preventing lupus.

bioRxiv · Apr 17, 2023Immunology

Patch repair protects cells from the small pore-forming toxin aerolysin

R. Thapa, P. A. Keyel

This study identifies patch repair as the primary mechanism cells use to resist aerolysin, a small pore-forming toxin, and shows that Ca2+ influx is essential for this process.

bioRxiv · Sep 22, 2022Cell Biology

Sphingolipids protect ergosterol in the Leishmania major membrane from sterol-binding toxins

C. Haram, S. Moitra, R. Keane, F. M. Kuhlmann, C. Frankfater, F.-f. Hsu, S. M. Beverley, K. Zhang, P. A. Keyel

This study investigates how sphingolipids in Leishmania major protect ergosterol from sterol-binding toxins, showing that ceramide reduces toxin cytotoxicity and enhances amphotericin B efficacy.

bioRxiv · Jun 15, 2022Microbiology

Structural features of Dnase1L3 responsible for serum antigen clearance

J. J. McCord, M. Engavale, E. Masoumzadeh, J. Villarreal, B. Mapp, M. P. Latham, P. A. Keyel, R. B. Sutton

This study identifies structural features of Dnase1L3 that enable its unique ability to degrade antigenic DNA complexes, preventing autoimmunity.

bioRxiv · Jan 19, 2022Biochemistry