OCT4 interprets and enhances nucleosome flexibility
C. MacCarthy, J. Huertas, C. Ortmeier, H. vom Bruch, D. Reinke, A. Sander, T. Bergbrede, H. Schoeler, V. Cojocaru
This study shows how Oct4, a pioneer factor, enhances nucleosome flexibility through specific sequence recognition and nonspecific DNA exploration, affecting chromatin dynamics.
bioRxiv · Apr 27, 2021Biophysics