Author

T. Bergbrede

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Cancer Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

A. Unger· 2 shared A. Ashouri· 1 shared A. Krook· 1 shared A. Sander· 1 shared B. M. Klebl· 1 shared C. Koolmeister· 1 shared C. M. Gustafsson· 1 shared C. MacCarthy· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersPhysiology

A. Unger

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Inhibition of mammalian mtDNA transcription paradoxically activates liver fatty acid oxidation to reverse diet-induced hepatosteatosis and obesity

S. Jiang, T. Yuan, L. S. Kremer, F. A. Rosenberger, F. M. Hansen, M. Borg, D. Rubalcava-Gracia, M. Mennuni, R. Filograna, D. Alsina, J. Misic, C. Koolmeister, L. Ren, O. Andersson, A. Unger, , N.-G. Larsson

The paper shows that inhibiting mitochondrial DNA transcription in mice increases fatty acid oxidation, reducing obesity and liver fat while decreasing oxidative phosphorylation capacity.

bioRxiv · Sep 22, 2023 · PreprintPhysiology

Reduced mitochondrial transcription sensitizes acute myeloid leukemia cells to BCL-2 inhibition

L. S. Arabanian, J. Adamsson, A. Unger, R. Di Lucrezia, T. Bergbrede, A. Ashouri, E. Larsson, P. Nussbaumer, B. M. Klebl, L. Palmqvist, C. M. Gustafsson

This study shows that inhibiting mitochondrial transcription with IMT sensitizes acute myeloid leukemia cells to BCL-2 inhibition, enhancing apoptosis and survival in mouse models.

bioRxiv · Sep 23, 2022 · PreprintCancer Biology

OCT4 interprets and enhances nucleosome flexibility

C. MacCarthy, J. Huertas, C. Ortmeier, H. vom Bruch, D. Reinke, A. Sander, T. Bergbrede, H. Schoeler, V. Cojocaru

This study shows how Oct4, a pioneer factor, enhances nucleosome flexibility through specific sequence recognition and nonspecific DNA exploration, affecting chromatin dynamics.

bioRxiv · Apr 27, 2021Biophysics