Author

J. Huertas

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biophysics· 5

Signature Assays, Organisms & Methods

Click to filter · or open tag

Assay:ChIP-seq· 3 Research Focus:chromatin & epigenetic regulation· 3 Approach:experimental assay· 3 Research Focus:protein folding & dynamics· 3 Approach:biophysical modeling· 2 Research Focus:cell signaling & trafficking· 2 Approach:statistical model· 2 Assay:structural biology· 2

Frequent Co-Authors

V. Cojocaru· 3 shared J. A. Joseph· 2 shared M. J. Maristany· 2 shared R. Collepardo-Guevara· 2 shared A. Aguirre Gonzalez· 1 shared A. Sander· 1 shared B. K. Agbetiameh· 1 shared C. M. MacCarthy· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersBiophysics

V. Cojocaru

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Tandem-repeat proteins introduce tuneable properties to engineered biomolecular condensates

T. L. C. Ng, M. P. Hoare, M. J. Maristany, E. J. Wilde, T. Sneideris, J. Huertas, B. K. Agbetiameh, M. Furukawa, J. A. Joseph, T. P. J. Knowles, R. Collepardo-Guevara, L. S. Itzhaki, J. R. Kumita

This study designs a synthetic biomolecular condensate platform using CTPR proteins and intrinsically-disordered domains to tune condensate properties and recruit target proteins.

bioRxiv · Apr 16, 2024Biophysics

Decoding Phase Separation of Prion-Like Domains through Data-Driven Scaling Laws

M. J. Maristany, A. Aguirre Gonzalez, J. R. Espinosa, J. Huertas, R. Collepardo-Guevara, J. A. Joseph

The paper uses a coarse-grained model to analyze how amino acid mutations affect the stability of prion-like domains across multiple proteins, revealing scaling laws that predict condensate behavior.

bioRxiv · Jun 14, 2023Biophysics

Histone tails cooperate to control the breathing of genomic nucleosomes

J. Huertas, H. R. Schöler, V. Cojocaru

The paper shows how histone H3 and H2A tails regulate nucleosome breathing through structural dynamics and epigenetic interactions.

PLOS Computational Biology · Jun 3, 2021Peer-reviewedBiophysics

OCT4 interprets and enhances nucleosome flexibility

C. MacCarthy, J. Huertas, C. Ortmeier, H. vom Bruch, D. Reinke, A. Sander, T. Bergbrede, H. Schoeler, V. Cojocaru

This study shows how Oct4, a pioneer factor, enhances nucleosome flexibility through specific sequence recognition and nonspecific DNA exploration, affecting chromatin dynamics.

bioRxiv · Apr 27, 2021Biophysics

Nucleosomal DNA dynamics mediate Oct4 pioneer factor binding

J. Huertas, C. M. MacCarthy, H. R. Schoeler, V. Cojocaru

This study shows that nucleosome dynamics enable Oct4 binding by correlating mobility with binding site availability and stable protein-DNA interactions.

bioRxiv · May 10, 2019Biophysics