Author

C. Marks

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Immunology· 7

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 4 Research Focus:cell type annotation· 3 Approach:deep learning· 3 Approach:experimental assay· 3 Assay:protein structure· 3 Assay:proteomics· 3 Research Focus:clustering· 2 Research Focus:database / resource· 2

Frequent Co-Authors

C. M. Deane· 5 shared M. I. J. Raybould· 5 shared A. Kovaltsuk· 3 shared A. P. Lewis· 3 shared J. Shi· 3 shared A. Bujotzek· 2 shared B. Taddese· 2 shared C. Deane· 2 shared

Activity by Year

2018-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

5 shared papersImmunology

C. M. Deane

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Epitope profiling of coronavirus-binding antibodies using computational structural modelling

S. A. Robinson, M. I. J. Raybould, C. Marks, C. Schneider, W. K. Wong, C. M. Deane

This paper introduces a computational method to profile epitopes of coronavirus-binding antibodies using structural modeling, revealing that sequence-dissimilar antibodies can bind the same epitope.

bioRxiv · Apr 12, 2021Immunology

Humanization of antibodies using a machine learning approach on large-scale repertoire data

M. Chin, C. Marks, C. M. Deane

This paper develops a machine learning tool, Hu-mAb, to computationally humanize antibodies by predicting mutations that reduce immunogenicity, outperforming existing methods and validated against experimental data.

bioRxiv · Jan 8, 2021Immunology

CoV-AbDab: the Coronavirus Antibody Database

M. I. J. Raybould, A. Kovaltsuk, C. Marks, C. M. Deane

The paper introduces CoV-AbDab, a database of antibodies against SARS-CoV-2 and related betacoronaviruses, providing metadata and analysis tools for research applications.

bioRxiv · May 15, 2020Immunology

Evidence of Antibody Repertoire Functional Convergence through Public Baseline and Shared Response Structures

M. I. J. Raybould, C. Marks, A. Kovaltsuk, A. P. Lewis, J. Shi, C. Deane

The paper investigates functional convergence in human antibody repertoires by analyzing structural commonality in baseline and response antibodies, finding high structural similarity across individuals.

bioRxiv · Mar 17, 2020Immunology

Structural Diversity of B-Cell Receptor Repertoires along the B-cell Differentiation Axis in Humans and Mice

A. Kovaltsuk, M. I. J. Raybould, W. K. Wong, C. Marks, S. Kelm, J. Snowden, J. Trück, C. M. Deane

The paper structurally characterizes B-cell receptor paratopes in humans and mice, showing structural differences across B-cell differentiation stages and conservation in naive repertoires.

bioRxiv · Sep 9, 2019Immunology

Thera-SAbDab: the Therapeutic Structural Antibody Database

M. I. J. Raybould, C. Marks, A. P. Lewis, J. Shi, A. Bujotzek, B. Taddese, C. Deane

Thera-SAbDab tracks therapeutic antibodies and nanobodies, linking them to structural data and metadata for sequence and target analysis.

bioRxiv · Aug 12, 2019Immunology

The Therapeutic Antibody Profiler (TAP): Five Computational Developability Guidelines

M. Raybould, C. Marks, K. Krawczyk, B. Taddese, J. Nowak, A. P. Lewis, A. Bujotzek, J. Shi, C. M. Deane

The paper introduces TAP, a tool that identifies developability issues in therapeutic antibodies using five computational guidelines based on structural and charge properties.

bioRxiv · Jun 29, 2018Immunology