Author

J. Snowden

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Organism:human· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:database / resource· 1 Research Focus:drug response / drug discovery· 1 Organism:rat· 1

Frequent Co-Authors

C. M. Deane· 3 shared A. Kovaltsuk· 2 shared S. Kelm· 2 shared A. Lawson· 1 shared A. Macpherson· 1 shared B. Holmes· 1 shared C. Marks· 1 shared D. I. Svergun· 1 shared

Activity by Year

2018-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersImmunology

C. M. Deane

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3 papers

Recent·Most cited

The allosteric modulation of Complement C5 by knob domain peptides

A. Macpherson, M. Laabei, Z. Ahdash, M. A. Graewert, J. Birtley, S. Schulze, S. Crennell, S. Robinson, B. Holmes, V. Oleinikovas, P. H. Nilsson, J. Snowden, V. Ellis, T. E. Mollnes, C. M. Deane, , J. van den Elsen

This study shows that knob domain peptides modulate complement C5 through allosteric mechanisms, revealing new therapeutic inhibitors and introducing knob domains as low molecular weight antibody fragments.

bioRxiv · Oct 24, 2020Immunology

Structural Diversity of B-Cell Receptor Repertoires along the B-cell Differentiation Axis in Humans and Mice

A. Kovaltsuk, M. I. J. Raybould, W. K. Wong, C. Marks, S. Kelm, J. Snowden, J. Trück, C. M. Deane

The paper structurally characterizes B-cell receptor paratopes in humans and mice, showing structural differences across B-cell differentiation stages and conservation in naive repertoires.

bioRxiv · Sep 9, 2019Immunology

Observed Antibody Space: a resource for data mining next generation sequencing of antibody repertoires

A. Kovaltsuk, J. Leem, S. Kelm, J. Snowden, C. M. Deane, K. Krawczyk

The paper introduces a resource called Observed Antibody Space (OAS) that curates and provides access to over half a billion antibody sequences from 53 studies for immune repertoire analysis.

bioRxiv · May 19, 2018Immunology