ApoC-III overexpression and LDLr-/- protect mice from DSS-colitis: identifying a new role for lipoprotein metabolism in Tregs
C. N. Rodia, D. Li, N. S. Tambini, Z. K. Johnson, E. R. Jellison, A. T. Vella, A. B. Kohan
This study shows that apoC-III overexpression and LDLr deficiency protect mice from DSS-colitis by increasing intestinal Tregs and IL-10, suggesting apoC-III as a potential therapeutic target for IBD.
bioRxiv · Nov 5, 2019 · PreprintPhysiology