Author

C. Niehrs

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Bioengineering· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

A. Hirth· 1 shared A. Svorinic· 1 shared C. Seidl· 1 shared C.-M. Cruciat· 1 shared D. Papageorgiou· 1 shared E. Fatti· 1 shared F. Da Silva· 1 shared G. Stier· 1 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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Curved chords = mutual co-authorship

1 shared paperBiochemistry

A. Hirth

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Primary Cilia are WNT Transducing Organelles whose Biogenesis is Regulated by a WNTPP1 axis

K. Zhang, F. Da Silva, C. Seidl, M. Wilsch-Bräuninger, J. Herbst, W. B. Huttner, C. Niehrs

The paper shows that primary cilia transduce WNT signals independently of β-catenin by regulating PP1 activity through the WNT/GSK3 pathway.

bioRxiv · Dec 9, 2022 · PreprintCell Biology

ROTACs leverage signaling-incompetent R-spondin for targeted protein degradation

R. Sun, H. Lee, C. Niehrs

This paper introduces ROTACs, signaling-incompetent R-spondin chimeras that target transmembrane proteins for degradation, demonstrating efficacy against PD-L1 in melanoma cells.

bioRxiv · Dec 8, 2022Bioengineering

DEAD-box RNA Helicases Act as Nucleotide Exchange Factors for Casein Kinase 2

E. Fatti, A. Hirth, A. Svorinic, M. Guenther, C.-M. Cruciat, G. Stier, S. P. Acebron, D. Papageorgiou, I. Sinning, J. Krijgsveld, T. Hoefer, C. Niehrs

The paper shows DDX proteins act as nucleotide exchange factors for CK22, enhancing kinase activity and revealing a new regulatory mechanism for protein kinases.

bioRxiv · Dec 20, 2021Biochemistry