CRYPTOCHROMES confer robustness, not rhythmicity, to circadian timekeeping
M. Putker, D. Wong, E. Seinkmane, N. M. Rzechorzek, A. Zeng, N. P. Hoyle, J. E. Chesham, M. D. Edwards, K. A. Feeney, R. Fischer, N. Peschel, K.-F. Chen, C. P. Selby, A. Sancar, J. S. O'Neill
The paper shows that circadian rhythms persist in mice lacking CRY, suggesting that transcriptional feedback is not essential for timekeeping, but rather contributes to robustness.
The EMBO Journal · Jan 25, 2021Peer-reviewedCell Biology