D. Wong

Utility of Cellular Measurements of Non-Specific Endocytosis to Assess the Target-Independent Clearance of Monoclonal Antibodies

The paper develops a cell-based assay to measure non-specific endocytosis of monoclonal antibodies and shows that high non-specific uptake correlates with target-independent clearance and low bioavailability.

A mutant fitness compendium in Bifidobacteria reveals molecular determinants of colonization and host-microbe interactions

The paper creates a mutant fitness compendium for Bifidobacterium breve to identify molecular factors affecting colonization and host-microbe interactions.

PI 3-kinase isoform p110α mediated FOXO1 inactivation protects against aortic aneurysm formation

This study shows that p110α-mediated FOXO1 inactivation in smooth muscle cells prevents aortic aneurysm formation by maintaining vascular homeostasis and promoting reparative SMC phenotypes.

The grape MYB24 mediates the coordination of light-induced terpene and flavonol accumulation in response to berry anthocyanin sunscreen depletion

The paper identifies MYB24 as a transcription factor coordinating light-induced terpene and flavonol accumulation in response to anthocyanin depletion in grape berries.

Effects of memantine and high dose vitamin D on gait in the APP/PS1 mouse model of Alzheimer's disease following vitamin D deprivation

This study examines how vitamin D deprivation and treatment with memantine and vitamin D affect gait in APP/PS1 mice, finding that the combination prevents gait impairment.

Carbapenem-Resistant Acinetobacter baumannii in US hospitals: diversification of circulating lineages and antimicrobial resistance

This study analyzes CRAb isolates from US hospitals using WGS, identifying new sub-lineages and resistance patterns, highlighting shifts in CRAb population structure and clinical impact.

CRYPTOCHROMES confer robustness, not rhythmicity, to circadian timekeeping

The paper shows that circadian rhythms persist in mice lacking CRY, suggesting that transcriptional feedback is not essential for timekeeping, but rather contributes to robustness.

Controlling swelling and release of hyaluronic acid during aqueous storage by in situ cross-linking during spray drying with alginate

This study develops a method to improve hyaluronic acid storage stability by encapsulating it in calcium cross-linked alginate microcapsules, showing reduced swelling and leaching.

ZEB1 insufficiency causes corneal endothelial cell state transition and altered cellular processing

This study shows that ZEB1 insufficiency in corneal endothelial cells leads to a MET-like transition, altering cellular phenotype and transcriptomic profile in a model of PPCD.

1H MR Spectroscopy of the Motor Cortex Immediately following Transcranial Direct Current Stimulation at 7 Tesla

This study uses 7T MRI to measure metabolite changes in the motor cortex after bihemispheric tDCS, finding a trend toward increased NAA/tCr and a strong correlation between NAA and tCr changes.