Setdb1 safeguards genome integrity in muscle stem cells to allow for regenerative myogenesis and inflammation
P. Garcia, W. Jarassier, C. Brun, L. Giordani, F. Agostini, W. H. Kung, C. Peccate, J. Ravent, S. Fall, V. Petit, T. Cheung, S. Ait-Si-Ali, F. Le Grand
This study shows that Setdb1 in muscle stem cells prevents endogenous retrovirus activation and maintains genome stability, which is essential for muscle regeneration and inflammation control.
bioRxiv · Jun 8, 2023 · PreprintCell Biology