L. Giordani

Setdb1 safeguards genome integrity in muscle stem cells to allow for regenerative myogenesis and inflammation

This study shows that Setdb1 in muscle stem cells prevents endogenous retrovirus activation and maintains genome stability, which is essential for muscle regeneration and inflammation control.

Myofiber stretch induces tensile and shear deformation of muscle stem cells in their native niche

This study shows that muscle stem cells in their native niche experience mechanical deformation from myofiber stretch-shortening and respond with increased nitric oxide production and gene expression related to proliferation.

GREM1 is epigenetically reprogrammed in muscle cells after exercise training and controls myogenesis and metabolism

This study identifies an epigenetic reprogramming of GREM1 in muscle cells after exercise training, which enhances myogenesis and metabolism through the AMPK pathway.

TGFβ signaling curbs cell fusion and muscle regeneration

This study shows that TGFβ signaling inhibits muscle cell fusion and regeneration, with inhibition promoting fusion and muscle repair.

High-dimensional single-cell cartography reveals novel skeletal muscle resident cell populations

This study maps adult skeletal muscle cell types using single-cell RNA-sequencing and mass cytometry, identifying two novel populations with myogenic potential.