Identification of a novel HIF-1α-αMβ2 Integrin-NETosis axis in fibrotic interstitial lung disease
A. A. Khawaja, D. L. W. Chong, J. Sahota, C. Pericleous, V. M. Ripoll, H. L. Booth, S. Khan, M. Rodriguez-Justo, I. P. Giles, J. C. Porter
This study identifies a novel HIF-1α-αMβ2 integrin-NETosis axis in fibrotic interstitial lung disease, showing hypoxia enhances NETosis and integrin expression.
bioRxiv · Jan 3, 2020Immunology