M. Rodriguez-Justo

Epigenome and early selection determine the tumour-immune evolutionary trajectory of colorectal cancer

This study shows that immune evasion in colorectal cancer follows a 'Big Bang' pattern, where early genetic and epigenetic changes drive subsequent tumor-immune evolution.

Context-dependent effects of CDKN2A and other 9p21 gene losses during the evolution of oesophageal cancer

The paper investigates how CDKN2A and other 9p21 gene losses influence oesophageal cancer progression, finding context-dependent effects on survival and immune infiltration.

Chemotherapeutic regulation of the ROS/MondoA-dependent TXNIP/GDF15 axis; and derivation of a new organoid metric as a predictive biomarker

The paper identifies chemotherapy-induced TXNIP as a negative regulator of GDF15 in CRC, showing its potential as a prognostic biomarker through organoid models.

FUME-TCRseq: Sensitive and accurate sequencing of the T-cell receptor from limited input of degraded RNA

FUME-TCRseq is a sensitive and accurate method for TCR sequencing from low-quality RNA, outperforming existing methods in detecting clonotypes and enabling analysis of archival tissue samples.

Phenotypic plasticity and genetic control in colorectal cancer evolution

This study investigates phenotypic plasticity and genetic control in colorectal cancer by analyzing gene expression and genetic variation across multiple tumor regions.

The co-evolution of the genome and epigenome in colorectal cancer

This study examines the co-evolution of genome and epigenome in colorectal cancer using single-clone spatial multi-omic profiling, revealing epigenetic changes and their impact on mutation accumulation.

Mutation Rate Evolution Drives Immune Escape In Mismatch Repair-Deficient Cancer

The paper shows that mutation rate adaptation in MMRd cancers drives immune escape by modulating neoantigen diversity and subclonal mutation rates.

Assessment of the evolutionary consequence of putative driver mutations in colorectal cancer with spatial multiomic data

This study uses spatial multiomic data to assess the evolutionary impact of putative driver mutations in colorectal cancer, identifying both genetic and non-genetic factors influencing subclonal expansion.

Immunogenomic profile of colorectal cancer response to immune checkpoint blockade

This study identifies immunogenomic features predicting response to immune checkpoint blockade in colorectal cancer, showing that high clonality and immune escape mechanisms are more important than mutational burden.

Identifying strategies to target the metabolic flexibility of tumours.

The paper identifies compensatory metabolic mechanisms in tumours and shows that targeting these can improve therapeutic outcomes.

Identification of a novel HIF-1α-αMβ2 Integrin-NETosis axis in fibrotic interstitial lung disease

This study identifies a novel HIF-1α-αMβ2 integrin-NETosis axis in fibrotic interstitial lung disease, showing hypoxia enhances NETosis and integrin expression.

Niche engineering drives early passage through an immune bottleneck in progression to colorectal cancer

The paper models tumor-immune dynamics in colorectal cancer progression, showing immune evasion enables transition from immune-hot adenomas to immune-cold carcinomas.