Cryo-EM structure of the complete and ligand-saturated insulin receptor ectodomain
T. Gutmann, I. Schaefer, C. Poojari, B. Brankatschk, I. Vattulainen, M. Strauss, U. Coskun
The paper reports the cryo-EM structure of the insulin receptor ectodomain with four insulin molecules, revealing two binding sites and a T-shaped conformation.
bioRxiv · Jun 21, 2019Biochemistry