M. Strauss

IFNγ initiates TLR9-dependent autoimmune hepatitis in DNase II deficient mice

This study shows that IFNγ initiates TLR9-dependent autoimmune hepatitis in DNase II deficient mice by promoting monocyte recruitment and lymphocyte activation.

Mutations in Fibronectin Dysregulate Chondrogenesis in Skeletal Dysplasia

This paper investigates how fibronectin mutations impair chondrogenesis in skeletal dysplasia by disrupting protein secretion and causing cellular stress in mesenchymal stem cells.

Microfibril-associated glycoprotein 4 forms octamers that mediate interactions with elastogenic proteins and cells

This study determines the cryo-EM structure of MFAP4, revealing its octameric assembly and functional interactions with elastogenic proteins and cells.

Structure and function of a hexameric cyanophycin synthetase 2

The paper reports cryo-EM structures of hexameric CphA2 from Stanieria sp., with and without ATP and cyanophycin, and shows how hexamerization enhances cyanophycin synthesis.

A paired liver biopsy and plasma proteomics study reveals circulating biomarkers for alcohol-related liver disease

This study identifies circulating proteomic biomarkers for alcohol-related liver disease using paired liver biopsy and plasma proteomics, showing improved performance over existing tests.

Cryo-EM structures reveal two distinct conformational states in a picornavirus cell entry intermediate.

The paper identifies two distinct conformational states of the 135S poliovirus particle using cryo-EM, showing that VP1 N-terminus externalization and VP4 retention vary between states.

Structural basis for VIPP1 oligomerization and maintenance of thylakoid membrane integrity

This study determines the structure of cyanobacterial VIPP1 rings using cryo-EM, revealing how VIPP1 oligomerization and lipid binding maintain thylakoid membrane integrity.

Structural basis for PRC2 decoding of active histone methylation marks H3K36me2/3

The paper determines how PRC2 is inhibited by H3K36 methylation through cryo-EM structures and shows that H3K36 mutations impair Polycomb repression.

The novel shapeshifting bacterial phylum Saltatorellota

This paper discovers a new bacterial phylum, Saltatorellota, capable of shape-shifting and amoeba-like movement, challenging the notion of bacterial morphological rigidity.

Giraffe Translocation Population Viability Analysis

This study uses Population Viability Analysis to determine optimal founding population sizes and sex ratios for giraffe translocations, finding that 50 females and 5 males are recommended for long-term viability.

Cryo-EM structure of the complete and ligand-saturated insulin receptor ectodomain

The paper reports the cryo-EM structure of the insulin receptor ectodomain with four insulin molecules, revealing two binding sites and a T-shaped conformation.

Structure of a cytochrome-based bacterial nanowire

Cryo-electron microscopy reveals the structure of a c-type cytochrome filament forming a bacterial nanowire in Geobacter sulfurreducens.