Author

C. Pou Casellas

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 1 Assay:CRISPR screen· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1

Frequent Co-Authors

A. Jamalpoor· 2 shared M. J. Janssen· 2 shared R. Masereeuw· 2 shared C. A. van Gelder· 1 shared C. M. Ammerlaan· 1 shared C. R. Berkers· 1 shared E. A. Zaal· 1 shared E. J. Wubbolts· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersBioengineering

A. Jamalpoor

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Gene surgery as a potential treatment option for Nephropathic Cystinosis in vitro

E. Sendino Garvi, J. Faria, C. Pou Casellas, S. Thijssen, E. J. Wubbolts, A. Jamalpoor, P. Harrison, R. Masereeuw, M. J. Janssen

This study uses CRISPR/Cas9 HITI to repair CTNS in ciPTEC cells, achieving functional cystinosin restoration and reversing the cystinotic phenotype.

bioRxiv · Nov 1, 2023 · PreprintBioengineering

Cysteamine-bicalutamide combination treatment restores alpha-ketoglutarate and corrects proximal tubule phenotype in cystinosis

A. Jamalpoor, C. A. van Gelder, F. A. Yousef Yengej, E. A. Zaal, S. P. Berlingerio, K. R. Veys, C. Pou Casellas, K. Voskuil, K. Essa, C. M. Ammerlaan, L. R. Rega, R. E. N. van der Welle, M. R. Lilien, M. B. Rookmaaker, H. Clevers, , M. J. Janssen

This study identifies alpha-ketoglutarate as a key metabolite in cystinosis and shows that combining cysteamine with bicalutamide corrects proximal tubule defects in cell models and zebrafish.

bioRxiv · Feb 10, 2020 · PreprintPharmacology & Toxicology