Author

R. Masereeuw

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 3 Cell Biology· 2 Pharmacology & Toxicology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 6 Approach:experimental assay· 5 Organism:human· 5 Research Focus:cell signaling & trafficking· 3 Research Focus:differential expression· 3 Research Focus:development & morphogenesis· 2 Research Focus:drug response / drug discovery· 2 Approach:genetic perturbation / CRISPR· 2

Frequent Co-Authors

M. J. Janssen· 4 shared A. Jamalpoor· 3 shared E. A. Zaal· 3 shared M. Altelaar· 3 shared A. M. van Genderen· 2 shared C. A. van Gelder· 2 shared C. Pou Casellas· 2 shared C. R. Berkers· 2 shared

Activity by Year

2020-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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Curved chords = mutual co-authorship

4 shared papersPharmacology & Toxicology

M. J. Janssen

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

A novel KCNJ16 kidney organoid model recapitulates the disease phenotype and shows restoration of lipid accumulation upon treatment with statins

E. Sendino Garvi, G. van der Slobbe, E. A. Zaal, J. H. F. de Baaij, J. Hoenderop, R. Masereeuw, M. J. Janssen, A. M. van Genderen

This paper develops a KCNJ16-depleted kidney organoid model to study a genetic kidney tubulopathy, showing that statin treatment reduces lipid accumulation and fibrosis.

bioRxiv · Dec 22, 2023 · PreprintCell Biology

Gene surgery as a potential treatment option for Nephropathic Cystinosis in vitro

E. Sendino Garvi, J. Faria, C. Pou Casellas, S. Thijssen, E. J. Wubbolts, A. Jamalpoor, P. Harrison, R. Masereeuw, M. J. Janssen

This study uses CRISPR/Cas9 HITI to repair CTNS in ciPTEC cells, achieving functional cystinosin restoration and reversing the cystinotic phenotype.

bioRxiv · Nov 1, 2023 · PreprintBioengineering

Differentiated kidney tubular cell-derived extracellular vesicles enhance maturation of tubuloids

R. S. Lindoso, F. A. Y. Yengej, F. Voellmy, M. Altelaar, E. M. Juncosa, T. Tsikari, C. M. E. Ammerlaan, B. W. M. Van Balkom, M. C. Verhaar, R. Masereeuw

This study shows that extracellular vesicles from kidney tubular cells enhance tubuloid maturation by increasing transport protein expression and triggering key biological pathways.

bioRxiv · Feb 8, 2022Cell Biology

Topographic Guidance in Melt-Electrowritten Tubular Scaffolds Enhances Engineered Kidney Tubule Performance

A. M. van Genderen, K. Jansen, M. Kristen, J. van Duijn, Y. Li, C. C. L. Schuurmans, J. Malda, T. Vermonden, J. Jansen, R. Masereeuw, M. Castilho

This paper develops small, porous tubular scaffolds using melt-electrowriting to enhance engineered kidney tubule functionality through microgeometry-directed cell behavior.

bioRxiv · Sep 16, 2020Bioengineering

The lysosomal V-ATPase B1 subunit in renal proximal tubule is linked to nephropathic cystinosis

A. Jamalpoor, A. van Eerde, M. R. Lilien, C. A. van Gelder, E. A. Zaal, F. A. Valentijn, R. Broekhuizen, E. Zielhuis, J. E. Egido, M. Altelaar, C. R. Berkers, R. Masereeuw, M. J. Janssen

The paper shows that ATP6V1B1 deficiency in renal proximal tubule cells causes cystine accumulation and autophagy activation, linking it to cystinosis.

bioRxiv · Jul 24, 2020 · PreprintPharmacology & Toxicology

A combined microphysiological-computational omics approach in dietary protein evaluation

P. G. Jochems, W. R. Keusters, A. H. P. America, P. C. Rietveld, S. Bastiaan-Net, R. M. Ariens, M. M. M. Tomassen, F. Lewis, Y. Li, K. G. Westphal, J. Garssen, H. J. Wichers, J. Van Bergenhenegouwen, R. Masereeuw

This study evaluates dietary protein sources using a combined experimental and computational approach, showing that protein source type does not drive clustering of bioactive peptide delivery potential.

bioRxiv · Jul 3, 2020Bioengineering

Cysteamine-bicalutamide combination treatment restores alpha-ketoglutarate and corrects proximal tubule phenotype in cystinosis

A. Jamalpoor, C. A. van Gelder, F. A. Yousef Yengej, E. A. Zaal, S. P. Berlingerio, K. R. Veys, C. Pou Casellas, K. Voskuil, K. Essa, C. M. Ammerlaan, L. R. Rega, R. E. N. van der Welle, M. R. Lilien, M. B. Rookmaaker, H. Clevers, , M. J. Janssen

This study identifies alpha-ketoglutarate as a key metabolite in cystinosis and shows that combining cysteamine with bicalutamide corrects proximal tubule defects in cell models and zebrafish.

bioRxiv · Feb 10, 2020 · PreprintPharmacology & Toxicology