PDGFRA Defines the Mesenchymal Stem Cell Kaposi’s Sarcoma Progenitors by Enabling KSHV Oncogenesis in an Angiogenic Environment
J. Naipauer, S. Rosario, S. Gupta, C. Premer, O. Mendez, M. Schlesinger, V. Ponzinibbio, V. Jain, L. Gay, R. Renne, H. L. Chan, L. Morey, D. Salyakina, M. Abba, S. Williams, , E. Mesri
The paper identifies PDGFRA+ bone marrow-derived mesenchymal stem cells as Kaposi’s sarcoma progenitors and shows pro-angiogenic conditions enable KSHV oncogenesis through epigenetic de-repression.
bioRxiv · Oct 2, 2019Cancer Biology