Author

C. R. L. Large

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 3

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Research Focus:chromatin & epigenetic regulation· 2 Approach:statistical model· 2 Organism:yeast· 2 Organism:C. elegans· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1

Frequent Co-Authors

M. J. Dunham· 2 shared A. Tsouris· 1 shared C. Huynh· 1 shared C. Kubo· 1 shared C. Smukowski Heil· 1 shared D. A. Moreno-Habel· 1 shared H. McConnellogue· 1 shared H. Takagi· 1 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersEvolutionary Biology

M. J. Dunham

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Author profile →

3 papers

Recent·Most cited

Lineage-resolved analysis of embryonic gene expression evolution in C. elegans and C. briggsae

C. R. L. Large, R. Khanal, L. W. Hillier, C. Huynh, C. Kubo, J. Kim, R. Waterston, J. I. Murray

This study compares gene expression patterns across embryonic development in C. elegans and C. briggsae to identify evolutionary constraints and divergence.

bioRxiv · Feb 3, 2024 · PreprintEvolutionary Biology

Genomic stability and adaptation of beer brewing yeasts during serial repitching in the brewery

C. R. L. Large, N. A. Hanson, A. Tsouris, O. Abou Saada, J. Koonthongkaew, Y. Toyokawa, T. Schmidlin, D. A. Moreno-Habel, H. McConnellogue, R. Preiss, H. Takagi, J. Schacherer, M. J. Dunham

This study tracks genomic changes in ale brewing yeast during serial repitching, showing reproducible aneuploidy and mitotic recombination across breweries.

bioRxiv · Jun 26, 2020 · PreprintEvolutionary Biology

Temperature preference biases parental genome retention during hybrid evolution

C. Smukowski Heil, C. R. L. Large, K. Patterson, M. J. Dunham

The paper shows that temperature preference influences genome retention in yeast hybrids, with specific alleles being lost or maintained based on environmental conditions and parental species traits.

bioRxiv · Sep 27, 2018Evolutionary Biology