M. J. Dunham

The genomic landscape of Saccharomyces paradoxus introgression in geographically diverse Saccharomyces cerevisiae strains

The paper identifies introgression from Saccharomyces paradoxus into Saccharomyces cerevisiae genomes using a hidden Markov model, finding widespread introgression with varying amounts and locations.

yEvo: a modular eukaryotic genetics and evolution research experience for high school students

yEvo provides high school students with modular yeast evolution experiments to explore mutation, adaptation, and evolution through hands-on research.

A modified fluctuation assay reveals a natural mutator phenotype that drives mutation spectrum variation within Saccharomyces cerevisiae

The paper uses a modified fluctuation assay to identify natural mutator phenotypes in S. cerevisiae strains, revealing a 10-fold mutation rate range and distinctive mutation spectra in two strains.

Genomic stability and adaptation of beer brewing yeasts during serial repitching in the brewery

This study tracks genomic changes in ale brewing yeast during serial repitching, showing reproducible aneuploidy and mitotic recombination across breweries.

The environmental stress response causes ribosome loss in aneuploid yeast cells.

This study clarifies that aneuploid yeast cells exhibit the environmental stress response (ESR) rather than the CAGE signature, leading to ribosome loss and reduced cellular density.

Transposon insertional mutagenesis in Saccharomyces uvarum reveals trans-acting effects influencing species dependent essential genes

This study uses transposon mutagenesis in Saccharomyces uvarum to identify species-dependent essential genes and shows that trans-acting factors influence gene essentiality despite cross-species complementation.

Temperature preference biases parental genome retention during hybrid evolution

The paper shows that temperature preference influences genome retention in yeast hybrids, with specific alleles being lost or maintained based on environmental conditions and parental species traits.