Fine Specificity Epitope Analysis by HX-MS Identifies Contact Points on Ricin Toxin Recognized by Protective Monoclonal Antibodies
G. Van Slyke, S. K. Angalakurthi, R. T. Toth, D. J. Vance, Y. Rong, D. Ehrbar, Y. Shi, C. R. Middaught, D. Volkin, D. Weis, N. Mantis
This study identifies protective monoclonal antibodies against ricin by mapping their epitopes using HX-MS and shows that specific contact points on RTA correlate with in vivo protection.
bioRxiv · Jun 14, 2018Immunology