Author

G. Van Slyke

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 5 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Assay:proteomics· 4 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

N. J. MANTIS· 4 shared D. Ehrbar· 2 shared D. J. Vance· 2 shared J. Doering· 2 shared K. Berman· 2 shared A. Damjanovic· 1 shared A. Dupuis· 1 shared C. R. Middaught· 1 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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4 shared papersImmunology

N. J. MANTIS

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Author profile →

6 papers

Recent·Most cited

Quantitating SARS-CoV-2 Neutralizing Antibodies from Human Dried Blood Spots

K. Berman, G. Van Slyke, H. Novak, J. Rock, R. Bievenue, A. Damjanovic, K. DeRosa, G. Mirabile, R. Giradin, A. Dupuis, K. McDonough, M. M. Parker, L. Styer, N. J. MANTIS

This study evaluates the use of dried blood spots (DBS) to quantify SARS-CoV-2 neutralizing antibodies using multiple assays, finding that DBS eluates can reliably measure neutralizing titers.

bioRxiv · Mar 18, 2024Immunology

Effects of aluminum-salt, CpG and emulsion adjuvants on the stability and immunogenicity of a virus-like particle displaying the SARS-CoV-2 receptor binding domain (RBD)

O. S. Kumru, S. Bajoria, K. Kaur, J. M. Hickey, G. Van Slyke, J. Doering, K. Berman, C. Richardson, H. Lien, H. Kleanthous, N. J. Mantis, S. B. Joshi, D. B. Volkin

This paper evaluates the stability and immunogenicity of a SARS-CoV-2 RBD VLP vaccine candidate formulated with different adjuvants and finds that AP and AH adjuvants provide comparable immunogenicity to AV, with AP showing higher neutralizing titers.

bioRxiv · Jul 10, 2023Immunology

The Flexible Linker of Decorin Binding Protein A from Borrelia burgdorferi is a Target of Antibodies in Lyme disease

E. Movahed, D. J. Vance, G. Van Slyke, D. Ehrbar, J. L. Yates, K. E. Kulas, M. J. Rudolph, N. J. Mantis

The paper identifies a specific DbpA epitope targeted by antibodies in Lyme disease patients, suggesting it may block B. burgdorferi colonization.

bioRxiv · Mar 3, 2022 · PreprintImmunology

Assessment of sample pooling for clinical SARS-CoV-2 testing

K. St. George, S. B. Griesemer, G. Van Slyke

The paper evaluates the effectiveness of sample pooling in SARS-CoV-2 testing, finding that weak positive samples are more likely to be missed in larger pools.

bioRxiv · May 26, 2020Microbiology

Endpoint and Epitope-specific Antibody Responses as Correlates of Vaccine-mediated Protection of Mice against Ricin Toxin

G. Van Slyke, D. J. Ehrbar, J. Doering, J. Yates, E. Vitetta, O. Donini, N. J. MANTIS

This paper develops a multivariate model using antibody endpoint titers and epitope-specific inhibition values to predict vaccine-mediated protection against ricin toxin in mice.

bioRxiv · May 6, 2020Immunology

Fine Specificity Epitope Analysis by HX-MS Identifies Contact Points on Ricin Toxin Recognized by Protective Monoclonal Antibodies

G. Van Slyke, S. K. Angalakurthi, R. T. Toth, D. J. Vance, Y. Rong, D. Ehrbar, Y. Shi, C. R. Middaught, D. Volkin, D. Weis, N. Mantis

This study identifies protective monoclonal antibodies against ricin by mapping their epitopes using HX-MS and shows that specific contact points on RTA correlate with in vivo protection.

bioRxiv · Jun 14, 2018Immunology