BiochemistrybioRxivPreprint
A Protein Engineering Approach for Uncovering Cryptic Ubiquitin-binding Sites: from a Ubiquitin-Variant Inhibitor of APC/C to K48 Chain Binding
E. R. Watson, C. R. R. Grace, W. Zhang…·B. A. Schulman
The paper identifies a cryptic ubiquitin-binding site on APC/C using ubiquitin variants, revealing its preference for K48-linked chains and demonstrating a method for uncovering such sites in large complexes.
DOI 10.1101/669846