Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
8 papers
Recent·Most cited
I. Schwartz, V. Budroni, M. Meyenberg, H. Hornegger, K. Hacker, S. Schwartz, Z. Hodakova, D. B. Grabarczyk, J. Ehrmann, S. Scinicariello, D. Haselbach, J. Menche, T. Clausen, E. Karagoez, G. A. Versteeg
The paper identifies UBR4, UBR5, and HUWE1 as E3 ligases that degrade cancer-associated APOBEC3 proteins to prevent genome mutagenesis.
bioRxiv · Apr 23, 2024Cell Biology
Z. Hodakova, I. Grishkovskaya, H. L. Brunner, D. L. Bolhuis, K. Belacic, A. Schleiffer, H. Kotisch, N. G. Brown, D. Haselbach
The paper presents the cryo-EM structure of UBR5, revealing its dimeric architecture and dynamic domain movements, and identifies AKIRIN2 as an interacting protein.
bioRxiv · Nov 3, 2022 · PreprintBiochemistry
K. F. Leesch, L. Lorenzo-Orts, C. Pribitzer, I. Grishkovskaya, M. Matzinger, E. Roitinger, K. Belacic, S. Kandolf, T.-Y. Lin, K. Mechtler, A. Meinhart, D. Haselbach, A. Pauli
The paper identifies conserved factors that maintain ribosome dormancy in zebrafish and Xenopus eggs and embryos, transitioning to an active state during early development.
bioRxiv · Nov 3, 2021Biochemistry
F. E. Morreale, S. Kleine, J. Leodolter, S. Ovchinnikov, J. Kley, R. Kurzbauer, D. M. Hoi, A. Meinhart, M. Hartl, D. Haselbach, M. Kaiser, T. Clausen
This paper develops BacPROTACs, small-molecule degraders that target bacterial proteins by activating the ClpC:ClpP protease, demonstrating in vivo degradation in mycobacteria.
bioRxiv · Jun 9, 2021Biochemistry
P. Gutierrez-Perez, E. M. Santillan, T. Lendl, A. C. Schrempf, T. L. Steinacker, M. Asparuhova, M. Brandstetter, D. Haselbach, L. Cochella
This study identifies miR-1 as a regulator of mitochondria and lysosome homeostasis in muscle cells, showing its conserved role in controlling V-ATPase and DCT-1/BNIP3.
bioRxiv · Aug 31, 2020 · PreprintCell Biology
A. R. Carvajal, C. G. Diaz, A. Vogel, A. Sonn-Segev, K. Schodl, L. Deszcz, Z. Orban-Nemeth, S. Sakamoto, K. Mechtler, P. Kukura, T. Clausen, D. Haselbach, F. Ikeda
This study shows LUBAC generates heterotypic ubiquitin chains with linear and oxyester-linked branches through coordinated action of HOIP and HOIL-1L.
bioRxiv · May 27, 2020Biochemistry
A. Sonn Segev, K. Belacic, T. Bodrug, G. Young, R. T. VanderLinden, B. Schulman, J. Schimpf, T. Friedrich, P. Vinh Dip, T. Schwartz, B. Bauer, J.-M. Peters, W. B. Struwe, J. L. Benesch, N. G. Brown, , P. Kukura
This paper demonstrates that mass photometry accurately quantifies sample heterogeneity with high resolution and minimal volume, outperforming negative stain electron microscopy in detecting proteasome assemblies.
bioRxiv · Dec 4, 2019Biophysics
E. R. Watson, C. R. R. Grace, W. Zhang, D. J. Miller, I. F. Davidson, J. R. Prabu, S. Yu, D. L. Bolhuis, E. T. Kulko, R. Vollrath, D. Haselbach, H. Stark, J.-M. Peters, N. G. Brown, S. S. Sidhu, B. A. Schulman
The paper identifies a cryptic ubiquitin-binding site on APC/C using ubiquitin variants, revealing its preference for K48-linked chains and demonstrating a method for uncovering such sites in large complexes.
bioRxiv · Jun 12, 2019 · PreprintBiochemistry