Pharmacology & ToxicologybioRxiv
Differential GLP-1R binding and activation by peptide and non-peptide agonists
X. Zhang, M. J. Belousoff, P. Zhao…·D. Wootten
The paper compares the binding and activation of the GLP-1 receptor by peptide and non-peptide agonists, revealing structural and functional differences that inform drug design.
DOI 10.1016/j.molcel.2020.09.020