Author

C. J. Langmead

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 3 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Research Focus:protein structure prediction· 2 Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1 Research Focus:development & morphogenesis· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

A. Christopoulos· 3 shared P. M. Sexton· 3 shared A. B. Tobin· 1 shared A. E. Berizzi· 1 shared A. Glukhova· 1 shared A. J. Kooistra· 1 shared C. R. Underwood· 1 shared C. Valant· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersPharmacology & Toxicology

A. Christopoulos

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4 papers

Recent·Most cited

Identifying promising sequences for protein engineering using a deep Transformer Protein Language Model

T. S. Frisby, C. J. Langmead

This paper introduces a deep Transformer Protein Language Model to identify promising protein sequences for engineering by calculating a PROMISE SCORE based on predicted interactions with binding partners.

bioRxiv · Feb 15, 2023Bioengineering

Differential GLP-1R binding and activation by peptide and non-peptide agonists

X. Zhang, M. J. Belousoff, P. Zhao, A. J. Kooistra, T. T. Truong, S. Y. Ang, C. R. Underwood, T. Egebjerg, P. Senel, G. D. Stewart, Y.-L. Liang, A. Glukhova, H. Venugopal, A. Christopoulos, S. G. Furness, , D. Wootten

The paper compares the binding and activation of the GLP-1 receptor by peptide and non-peptide agonists, revealing structural and functional differences that inform drug design.

bioRxiv · Aug 16, 2020Pharmacology & Toxicology

Pharmacological insights into safety and efficacy determinants for the development of adenosine receptor biased agonists in the treatment of heart failure

P. Rueda, J. Merlin, S. Chimenti, M. Feletou, J. Paysant, P. J. White, A. Christopoulos, P. M. Sexton, R. J. Summers, W. N. Charman, L. T. May, C. J. Langmead

This study compares the safety and efficacy of A1R agonists, showing that biased agonism away from Ca2+ influx relative to cAMP improves safety but may not guarantee efficacy in heart failure.

bioRxiv · Jul 22, 2020Pharmacology & Toxicology

Crystal structure of the M5 muscarinic acetylcholine receptor

Z. Vuckovic, P. R. Gentry, A. E. Berizzi, K. Hirata, S. Varghese, G. Thompson, E. T. van der Westhuizen, W. A. C. Burger, R. Rahmani, C. Valant, C. J. Langmead, C. W. Lindsley, J. Baell, A. B. Tobin, P. M. Sexton, , D. M. Thal

The paper reports the crystal structure of the human M5 muscarinic acetylcholine receptor bound to tiotropium, revealing structural differences that inform ligand selectivity design.

bioRxiv · Aug 14, 2019Pharmacology & Toxicology