Author

D. E. Gloriam

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Assay:fluorescence / live-cell microscopy· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

A. Christopoulos· 1 shared A. Glukhova· 1 shared A. J. Kooistra· 1 shared A. Mancini· 1 shared A. S. Hauser· 1 shared B. Breton· 1 shared C. Avet· 1 shared C. J. Langmead· 1 shared

Activity by Year

2020-2020 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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Curved chords = mutual co-authorship

1 shared paperPharmacology & Toxicology

A. Christopoulos

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Differential GLP-1R binding and activation by peptide and non-peptide agonists

X. Zhang, M. J. Belousoff, P. Zhao, A. J. Kooistra, T. T. Truong, S. Y. Ang, C. R. Underwood, T. Egebjerg, P. Senel, G. D. Stewart, Y.-L. Liang, A. Glukhova, H. Venugopal, A. Christopoulos, S. G. Furness, , D. Wootten

The paper compares the binding and activation of the GLP-1 receptor by peptide and non-peptide agonists, revealing structural and functional differences that inform drug design.

bioRxiv · Aug 16, 2020Pharmacology & Toxicology

A genetically encoded red fluorescence dopamine biosensor enables dual imaging of dopamine and norepinephrine

C. Nakamoto, Y. Goto, Y. Tomizawa, Y. Fukata, M. Fukata, K. Harpsoe, D. E. Gloriam, K. Aoki, T. Takeuchi

This paper develops a red fluorescent dopamine biosensor with high selectivity over norepinephrine, enabling dual-color imaging of both neuromodulators in vitro.

bioRxiv · May 25, 2020Cell Biology

Effector membrane translocation biosensors reveal G protein and β-arrestin coupling profiles of 100 therapeutically relevant GPCRs

C. Avet, A. Mancini, B. Breton, C. Le Gouill, A. S. Hauser, C. Normand, H. Kobayashi, F. Gross, M. Hogue, V. Lukasheva, S. St-Onge, M. Carrier, M. Heroux, S. Morissette, E. Fauman, , M. Bouvier

The paper develops EMTA biosensors to profile G protein and β-arrestin coupling of 100 GPCRs, revealing diverse signaling profiles and drug-target interactions.

bioRxiv · Apr 20, 2020Pharmacology & Toxicology