Quantitative Mass Spectrometry Imaging Reveals Mutation Status-independent Lack of Imatinib Penetration into Liver Metastases of Gastrointestinal Stromal Tumors
D. Abu Sammour, C. Marsching, A. Geisel, K. Erich, S. Schulz, C. Ramallo Guevara, J.-H. Rabe, A. Marx, P. Findeisen, P. Hohenberger, C. Hopf
The paper uses MSI to show imatinib does not penetrate GIST liver metastases, despite being present in healthy liver tissue, suggesting mutation-independent resistance.
bioRxiv · Feb 27, 2019Pharmacology & Toxicology