Author

C. Hopf

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 5 Cancer Biology· 2 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Organism:human· 7 Approach:experimental assay· 6 Assay:metabolomics· 4 Research Focus:cell type annotation· 3 Research Focus:drug response / drug discovery· 3 Assay:proteomics· 3 Research Focus:differential expression· 2 Assay:imaging· 2

Frequent Co-Authors

S. Schmidt· 4 shared T. Enzlein· 4 shared A. Geisel· 2 shared A. Marx· 2 shared D. Abu Sammour· 2 shared F. Keller· 2 shared L. Chavez-Gutierrez· 2 shared R. Rudolf· 2 shared

Activity by Year

2019-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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4 shared papersBiochemistry

S. Schmidt

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Label-free Assessment of Complement-Dependent Cytotoxicity of Therapeutic Antibodies via a Whole-Cell MALDI Mass Spectrometry Bioassay

S. Schmidt, A. Geisel, T. Enzlein, B. C. Froehlich, L. Pritchett, M. Verneret, C. Graf, C. Hopf

This study develops a label-free MALDI-TOF mass spectrometry bioassay to assess complement-dependent cytotoxicity of Rituximab, identifying metabolite markers and demonstrating robust concentration-response characteristics.

bioRxiv · May 3, 2024Biochemistry

Deep MALDI-MS Spatial Omics guided by Quantum Cascade Laser Mid-infrared Imaging Microscopy

L. Gruber, S. Schmidt, T. Enzlein, H. G. Vo, J. L. Cairns, Y. Ucal, F. Keller, D. Abu Sammour, R. Rudolf, M. Eckhardt, S. A. Iakab, L. Bindila, C. Hopf

This paper introduces a method combining quantum cascade laser infrared imaging with mass spectrometry to improve molecular identification in spatial omics, achieving high-resolution lipidomics profiling.

bioRxiv · Dec 14, 2023Biochemistry

APP substrate ectodomain defines A beta length by restraining gamma-secretase processivity and facilitating product release

M. Koch, T. Enzlein, S.-Y. Chen, D. Petit, S. Lismont, M. Zacharias, C. Hopf, L. Chavez-Gutierrez

The paper investigates how the APP ectodomain regulates gamma-secretase processivity and A beta peptide length, identifying it as a target for Alzheimer's disease therapies.

bioRxiv · Sep 13, 2023 · PreprintBiochemistry

Alzheimer's disease linked Aβ42 exerts product feedback inhibition on γ-secretase impairing downstream cell signaling

K. M. Zoltowska, U. Das, S. Lismont, T. Enzlein, M. Maesako, M. C. Houser, D. Gomes Moreira, M. L. Franco, B. Ozcan, D. Karachentsev, A. Becker, C. Hopf, M. Vilar, O. Berezovska, W. Mobley, L. Chavez-Gutierrez

This study shows that human Aβ42 inhibits γ-secretase, leading to substrate accumulation and neuronal dysfunction, suggesting a feedback mechanism in Alzheimer's disease.

bioRxiv · Aug 2, 2023Biochemistry

Spatial omics imaging of fresh-frozen tissue and routine FFPE histopathology on a single cancer needle core biopsy: freezing device and multimodal workflow

M. F. Rittel, S. Schmidt, C.-A. Weis, E. Birgin, B. van Marwick, M. Raedle, S. Diehl, N. Rahbari, A. Marx, C. Hopf

The paper develops a device and workflow for multimodal spatial omics analysis of fresh-frozen and FFPE-processed needle biopsy cores to enable simultaneous molecular and histopathological analysis of cancer tissue.

bioRxiv · Feb 11, 2023Cancer Biology

3D-Mass Spectrometry Imaging of Micro-scale 3D Cell Culture Models in Cancer Research

S. A. Iakab, F. Keller, S. Schmidt, J. Cordes, Q. Zhou, J. J. Cairns, F. Fischer, R. Schneider, I. Wolf, R. Rudolf, C. Hopf

The paper presents a 3D-MSI platform for analyzing lipid distribution in 3D cell cultures, revealing metabolic interactions in cancer models.

bioRxiv · Dec 5, 2022 · PreprintCancer Biology

Pre-analytical processing of plasma and serum samples for combined proteome and metabolome analysis

H. M. Gegner, T. Naake, A. Dugourd, T. Mueller, F. Czernilofsky, G. Kliewer, E. Jaeger, B. Helm, N. Kunze-Rohrbach, U. Klingmueller, C. Hopf, C. Mueller-Tidow, S. Dietrich, J. Saez-Rodriguez, W. Huber, , J. Krijgsveld

This study evaluates pre-analytical factors affecting plasma and serum proteome and metabolome stability, recommending standardized protocols for clinical use.

bioRxiv · Apr 26, 2022Biochemistry

Quantitative Mass Spectrometry Imaging Reveals Mutation Status-independent Lack of Imatinib Penetration into Liver Metastases of Gastrointestinal Stromal Tumors

D. Abu Sammour, C. Marsching, A. Geisel, K. Erich, S. Schulz, C. Ramallo Guevara, J.-H. Rabe, A. Marx, P. Findeisen, P. Hohenberger, C. Hopf

The paper uses MSI to show imatinib does not penetrate GIST liver metastases, despite being present in healthy liver tissue, suggesting mutation-independent resistance.

bioRxiv · Feb 27, 2019Pharmacology & Toxicology