A. Marx

Spatial omics imaging of fresh-frozen tissue and routine FFPE histopathology on a single cancer needle core biopsy: freezing device and multimodal workflow

The paper develops a device and workflow for multimodal spatial omics analysis of fresh-frozen and FFPE-processed needle biopsy cores to enable simultaneous molecular and histopathological analysis of cancer tissue.

Water stabilizes an alternate turn conformation in horse heart myoglobin

The paper identifies a water molecule stabilizing an alternate turn conformation in horse heart myoglobin, which reverts in simulations without the water.

A human RNA ligase that operates via auto- and RNA-AMPylation

This study identifies C12orf29 as a human 5-3 RNA ligase that uses auto- and RNA-AMPylation to catalyze RNA ligation and maintain RNA integrity under stress.

The interactome of site-specifically acetylated linker histone H1

This study generates site-specifically acetylated H1.2 and identifies its acetylation-dependent interactome, showing distinct interacting partners and involvement of SIRT1.

Serial femtosecond and serial synchrotron crystallography yield data of equivalent quality: a systematic comparison

This study compares data quality from serial femtosecond and serial synchrotron crystallography for two proteins, finding equivalent quality regardless of radiation source.

Extreme intratumour heterogeneity and driver evolution in mismatch repair deficient gastro-oesophageal cancer

This study investigates the evolution of mismatch repair deficient gastro-oesophageal cancers using multi-region exome sequencing, revealing extreme intratumour heterogeneity and key genetic events.

Quantitative Mass Spectrometry Imaging Reveals Mutation Status-independent Lack of Imatinib Penetration into Liver Metastases of Gastrointestinal Stromal Tumors

The paper uses MSI to show imatinib does not penetrate GIST liver metastases, despite being present in healthy liver tissue, suggesting mutation-independent resistance.