Targeting the glycan epitope type I N-acetyllactosamine enables immunodepletion of human pluripotent stem cells from early differentiated cells
C. Rossdam, S. Brand, J. Beimdiek, A. Oberbeck, M. D. Albers, O. Naujok, F. F. R. Buettner
The paper identifies T1LN as a glycan epitope specific to human pluripotent stem cells (hPSCs) that is rapidly downregulated during differentiation, enabling its use for immunodepletion of hPSCs from differentiated cell populations.
bioRxiv · Aug 30, 2023Cell Biology