J. Schmitz

Viewing stomata in action: Autonomous in planta imaging of individual stomatal movement

This study develops a microscope system to image stomatal movement in plants, revealing differences in response to light changes between maize and chrysanthemum.

Combinatorial optimization of pathway, process and media for the production of p-coumaric acid by Saccharomyces cerevisiae

This study optimizes p-coumaric acid production in Saccharomyces cerevisiae by combining statistical experimental design with process and genetic factors, achieving a 168-fold increase in titer.

Machine learning-guided optimization of p-coumaric acid production in yeast

The paper uses machine learning to optimize p-coumaric acid production in yeast through DBTL cycles, achieving a 68% increase in production.

Proteomic adaptations in the kidney reveal orchestration of local and secreted antimicrobial peptides in human pyelonephritis

This study identifies proteomic adaptations in human pyelonephritis, revealing elevated antimicrobial peptides and their potential protective role against systemic inflammation.

Neolactotetraosylceramide: A novel non-invasive urinary biomarker for bladder cancer

This paper identifies neolactotetraosylceramide (nLc4) as a non-invasive urinary biomarker for bladder cancer, showing higher levels in cancer tissues and urine exosomes with high specificity.

Viridiplantae-specific GLXI and GLXII isoforms co-evolved and detoxify glucosone in planta

The paper identifies two distinct glyoxalase systems in plants, showing one evolved from eukaryotes and the other acquired via horizontal gene transfer, with unique structural and functional adaptations for detoxifying reactive carbonyl species.

Reliable cell retention of mammalian suspension cells in microfluidic cultivation chambers

The paper introduces a microfluidic trapping method to retain suspension cells in cultivation chambers, preventing cell loss while allowing media diffusion.

Enzyme-constrained models predict the dynamics of Saccharomyces cerevisiae growth in continuous, batch and fed-batch bioreactors

This study improves metabolic models for yeast by incorporating enzyme constraints, enhancing their predictive accuracy in bioreactor simulations.

Growth and eGFP-production of CHO-K1 suspension cells cultivated from single-cell to lab-scale

This study compares growth, morphology, and eGFP production of CHO-K1 cells across microfluidic, shake flask, and lab-scale bioreactor systems, showing high comparability and highlighting MSCC's potential for bioprocess development.

A 4-lineage statistical suite to evaluate the support of large-scale retrotransposon insertion data to reconstruct evolutionary trees

The paper introduces a 4-lineage statistical test to evaluate retrotransposon insertion data for reconstructing evolutionary trees, supporting more complex topologies than previous methods.

Development and application of a cultivation platform for mammalian suspension cell lines with single-cell resolution (MaSC)

The paper develops a microfluidic platform for single-cell cultivation of mammalian suspension cells and demonstrates its ability to detect heterogeneous growth behaviors previously undetectable in bulk analyses.

Loss of TP53 mediates suppression of Macrophage Effector Function via Extracellular Vesicles and PDL1 towards Resistance against Chemoimmunotherapy in B-cell malignancies

This paper identifies that TP53 loss in B-cell lymphoma leads to resistance against chemoimmunotherapy by suppressing macrophage effector function through PDL1-expressing extracellular vesicles.

Systems-level analysis of monocyte responses in inflammatory bowel disease identifies IL-10 and IL-1 cytokine networks that regulate IL-23

The paper identifies IL-10 and IL-1 cytokine networks that regulate IL-23 production in monocytes, distinguishing homeostatic from hyper-inflammatory IL-23 production in inflammatory bowel disease.

Life out of water: Genomic and physiological mechanisms underlying skin phenotypic plasticity

This study identifies genomic and physiological mechanisms enabling skin plasticity in amphibious killifish during terrestrial acclimation, revealing adaptations for barrier function, respiration, and ion regulation.

De-novo emergence and template switching of SINE retroposons during the early evolution of passerine birds

This study uses SINE retroposon presence/absence patterns to resolve passerine bird phylogeny, finding SINE activity in their common ancestor and recent activity in suboscines via template switching.