A single dose of antibody-drug conjugate cures a stage 1 model of African trypanosomiasis.
P. MacGregor, A. L. Gonzalez-Munoz, F. Jobe, M. C. Taylor, S. Rust, A. M. Sandercock, O. J. S. Macleod, K. Van Bocxlaer, A. F. Francisco, F. D'Hooge, A. Tiberghien, C. S. Barry, P. Howard, M. K. Higgins, T. Vaughan, , M. Carrington
This paper demonstrates that a single dose of an antibody-drug conjugate targeting the trypanosome receptor HpHbR completely cures a stage 1 mouse model of African trypanosomiasis.
bioRxiv · Feb 11, 2019Microbiology