M. Carrington

Molecular mechanism of complement inhibition by the trypanosome receptor ISG65

This paper reveals how the trypanosome receptor ISG65 binds C3b through two sites, acting as a decoy and blocking complement receptors to reduce pathogen clearance.

Intron-loss in Kinetoplastea correlates with a non-functional EJC and loss of NMD factors

This study shows that Trypanosoma brucei lacks a functional EJC and NMD pathway due to intron loss and gene redundancy.

Understanding the heterogeneity of alloreactive natural killer cell function inkidney transplantation

This study identifies NK cell subpopulations and their functional responses in kidney transplant patients, linking pre-transplant NK cell characteristics to long-term graft function.

Mass spectrometric profiling of HLA-B44 peptidomes provides evidence for tapasin-mediated tryptophan editing

The paper compares HLA-B44 peptidomes with and without tapasin to show tapasin influences C-terminal tryptophan residues and peptide binding affinity.

Genome-wide subcellular protein localisation in the flagellate parasite Trypanosoma brucei

The paper maps subcellular protein localization in Trypanosoma brucei using fluorescence microscopy, revealing functional insights and organelle adaptations.

NKG2A and HLA-E define a novel alternative immune checkpoint axis in bladder cancer

This study identifies NKG2A and HLA-E as an alternative immune checkpoint axis in bladder cancer, showing NKG2A+ CD8 T cells can bypass HLA-ABC loss through TCR-independent cytotoxicity.

Black-necked spitting cobra (Naja nigricollis) phospholipases A2 cause Trypanosoma brucei death by blocking endocytosis through the flagellar pocket

This study shows that phospholipases A2 from Black-necked spitting cobra venom block Trypanosoma brucei endocytosis by enlarging the flagellar pocket and disrupting Rab11 localization, leading to cell cycle arrest.

Transmission of Candidatus Anaplasma camelii to laboratory animals by camel-specific keds, Hippobosca camelina

This study demonstrates that camel keds can transmit Candidatus Anaplasma camelii from infected camels to laboratory animals, highlighting their potential as a vector for anaplasmosis.

Parental-fetal interplay of immune genes leads to intrauterine growth restriction

This study identifies a maternal-fetal immune interaction involving KIR2DL1 and HLA-C*05 that causes intrauterine growth restriction in a humanised mouse model.

Genetically Determined Strength of Natural Killer Cells is Enhanced by Adaptive HLA class I Admixture in East Asians

The paper shows that East Asian populations, particularly the Chinese Southern Han, have enhanced NK cell strength due to genetic admixture and natural selection of HLA class I alleles that interact with inhibitory KIR receptors.

Robust computational design and evaluation of peptide vaccines for cellular immunity with application to SARS-CoV-2

The paper develops a machine learning method to design peptide vaccines for SARS-CoV-2, achieving high predicted coverage and robustness against epitope drift.

Predicting the Immunogenicity of T cell epitopes: From HIV to SARS-CoV-2

The paper presents a physics-based model predicting T cell epitope immunogenicity across pathogens, finding that only some SARS-CoV-2 epitopes are immunogenic and some are shared with low-pathogenicity coronaviruses.

Positively selected modifications in the pore of TbAQP2 allow pentamidine to enter Trypanosoma brucei

The paper identifies mutations in TbAQP2 that enable pentamidine permeation, showing how specific structural changes in the aquaporin pore allow drug entry in Trypanosoma brucei.

A single dose of antibody-drug conjugate cures a stage 1 model of African trypanosomiasis.

This paper demonstrates that a single dose of an antibody-drug conjugate targeting the trypanosome receptor HpHbR completely cures a stage 1 mouse model of African trypanosomiasis.

A new reporter cell line for studies with proteasome inhibitors in Trypanosoma brucei

This paper describes a Trypanosoma brucei cell line that uses GFP to visually monitor proteasome activity through inhibitor treatment.