Author

O. J. S. Macleod

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:Arabidopsis· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

M. Carrington· 2 shared A. F. Francisco· 1 shared A. H. Laustsen· 1 shared A. L. Gonzalez-Munoz· 1 shared A. M. Sandercock· 1 shared A. Martos-Esteban· 1 shared A. Tiberghien· 1 shared C. S. Barry· 1 shared

Activity by Year

2019-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersMicrobiology

M. Carrington

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2 papers

Recent·Most cited

Black-necked spitting cobra (Naja nigricollis) phospholipases A2 cause Trypanosoma brucei death by blocking endocytosis through the flagellar pocket

A. Martos-Esteban, O. J. S. Macleod, I. Maudlin, K. Kalogeropoulos, J. A. Jurgensen, M. Carrington, A. H. Laustsen

This study shows that phospholipases A2 from Black-necked spitting cobra venom block Trypanosoma brucei endocytosis by enlarging the flagellar pocket and disrupting Rab11 localization, leading to cell cycle arrest.

bioRxiv · Nov 1, 2021 · PreprintMicrobiology

A single dose of antibody-drug conjugate cures a stage 1 model of African trypanosomiasis.

P. MacGregor, A. L. Gonzalez-Munoz, F. Jobe, M. C. Taylor, S. Rust, A. M. Sandercock, O. J. S. Macleod, K. Van Bocxlaer, A. F. Francisco, F. D'Hooge, A. Tiberghien, C. S. Barry, P. Howard, M. K. Higgins, T. Vaughan, , M. Carrington

This paper demonstrates that a single dose of an antibody-drug conjugate targeting the trypanosome receptor HpHbR completely cures a stage 1 mouse model of African trypanosomiasis.

bioRxiv · Feb 11, 2019Microbiology