A single cell atlas reveals distinct immune landscapes in transplant and primary tumors that determine response or resistance to immunotherapy
A. J. Wisdom, Y. M. Mowery, C. S. Hong, X. Qin, D. Zhang, J. E. Himes, L. Chen, H. Fradin, E. S. Muise, E. S. Xu, D. J. Carpenter, C. L. Kent, K. S. Smythe, N. Williams, L. Luo, , D. G. Kirsch
The paper compares immune landscapes in transplant and primary tumors after immunotherapy and radiotherapy, finding that transplant tumors respond better due to CD8+ T cell enrichment.
bioRxiv · Mar 11, 2020Cancer Biology