Y. M. Mowery

Enhancing radiotherapy response via intratumoral injection of the TLR9 agonist CpG to stimulate CD8 T cells in an autochthonous mouse model of sarcoma

This study shows that combining radiotherapy with CpG, a TLR9 agonist, enhances tumor response in a mouse sarcoma model by boosting CD8 T cell activity.

Both CD8 and CD4 T cells contribute to immunosurveillance preventing the development of neoantigen-expressing autochthonous sarcomas

This study develops an autochthonous murine sarcoma model and shows that both CD8 and CD4 T cells are required for immunosurveillance against neoantigen-expressing tumors.

Temporary knockdown of p53 during focal limb irradiation increases the development of sarcomas

This study shows that temporarily knocking down p53 during radiation therapy increases the risk of sarcoma development in mice.

A single cell atlas reveals distinct immune landscapes in transplant and primary tumors that determine response or resistance to immunotherapy

The paper compares immune landscapes in transplant and primary tumors after immunotherapy and radiotherapy, finding that transplant tumors respond better due to CD8+ T cell enrichment.

The impact of respiratory gating on improving volume measurement of murine lung tumors in micro-CT imaging

This study evaluates how respiratory gating improves the accuracy and precision of lung tumor volume measurements in micro-CT imaging of mice.

Bridging the translational gap: Implementation of multimodal small animal imaging strategies for tumor burden assessment in a co-clinical trial

The paper develops and validates quantitative imaging protocols for preclinical tumor burden assessment in a co-clinical trial using multimodal small animal imaging.